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  • Title: Comparison of laser speckle contrast imaging and laser-Doppler fluxmetry in boys and men.
    Author: Hodges GJ, Klentrou P, Cheung SS, Falk B.
    Journal: Microvasc Res; 2020 Mar; 128():103927. PubMed ID: 31593712.
    Abstract:
    OBJECTIVE: We compare microvascular reactivity assessed by laser-Doppler fluxmetry (LDF) and laser speckle contrast imaging (LSCI) of boys and men during rest, post-occlusive reactive hyperaemia (PORH), and cycling exercise. METHODS: 19 boys (9 ± 1 y) and 18 men (22 ± 2 y) participated. LDF and LSCI measures were taken of the forearm during rest, PORH, and exercise. RESULTS: For all 3 assessments, the LSCI presented with higher flux values than the LDF for both boys and men (p < 0.001). Bland-Altman analyses indicated that there was a positive linear bias between LSCI and LDF measurements in both boys and men. Regression analyses showed that the responses for the two methods were variable, depending on the particular assessment. For instance, at rest in boys there was no relationship between LDF and LSCI (r2 = 0.002), while in men there was a strong relationship (r2 = 0.86). CONCLUSIONS: LSCI presented with higher values than LDF during rest, PORH, and exercise; the disparity between the two measures was larger as blood flow increased. The assessments were generally consistent, both methods appear to provide usable data for the assessment of microvascular reactivity in both boys and men. There are biases to each method and the data are not interchangeable between LDF and LSCI.
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