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  • Title: [Ultrastructural stereological analysis of the absolute parameters of the cardiomyocytes in myocardial hypertrophy].
    Author: Lushnikova EL, Nepomniashchikh LM.
    Journal: Biull Eksp Biol Med; 1985 May; 99(5):619-22. PubMed ID: 3159439.
    Abstract:
    Arterial hypertension was produced in male Wistar rats by abdominal aorta ligation. By the 35th day of experiment the animals had developed myocardial hypertrophy. The subcellular organization of cardiomyocytes was studied by electron microscopy and stereology (computation of relative and absolute parameters). In myocardial hypertrophy, the absolute volume of myofibrils, sarcoplasmic reticulum and T system in the left ventricle of the heart was increased, whereas the absolute volume of the mitochondria remained unchanged. The general surface area of all organelles was noticeably increased. The myofibrils and sarcoplasmic reticulum experienced greater changes, which may reflect the features of compensatory processes under the experimental conditions described.
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