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  • Title: Suppression of generation of concomitant antitumor immunity by passively transferred suppressor T cells from tumor-bearing donors.
    Author: Bursuker I, North RJ.
    Journal: Cancer Immunol Immunother; 1985; 19(3):215-8. PubMed ID: 3159472.
    Abstract:
    Infusion of normal recipient mice with suppressor T cells from donors bearing a progressive Meth A fibrosarcoma results in a diminished capacity of the recipients to generate concomitant and postexcision antitumor immunity. The passive transfer of suppressor cells which prevented the generation of immunity to the Meth A fibrosarcoma did not affect the capacity of the recipients to reject an allogeneic tumor. The data provides direct evidence in support of the hypothesis that suppressor T cells, generated at later stages of growth of Meth A fibrosarcoma, function to down-regulate an already acquired mechanism of concomitant immunity.
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