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  • Title: Cytophilic IgE on human blood and tissue eosinophils.
    Author: Capron M, Kusnierz JP, Prin L, Spiegelberg HL, Khalife J, Tonnel AB, Capron A.
    Journal: Int Arch Allergy Appl Immunol; 1985; 77(1-2):246-8. PubMed ID: 3159685.
    Abstract:
    Flow microfluorometry (FMF) was used to investigate the presence of cytophilic Ig (IgE or IgG) and the proportion of Fc receptor (Fc epsilon R or Fc gamma R)-bearing eosinophils among eosinophils from 21 hypereosinophilic patients. In 75% of the cases, it was possible to detect cytophilic IgE, significantly associated with serum IgE levels. Moreover, when lung and blood eosinophils were compared, the proportion of occupied Fc epsilon R was significantly increased on lung eosinophils, whereas very few cells had cytophilic IgG. This work provides further evidence that cytophilic IgE is not restricted to cells with high-affinity Fc epsilon R but can also be detected on the cell populations with low-affinity IgE receptors. These findings support the view that eosinophils can act as effector cells in immediate hypersensitivity reactions and in diseases associated with increased IgE production and hypereosinophilia.
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