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  • Title: Effects of three histaminergic compounds on function and oxygen consumption of isolated guinea-pig hearts.
    Author: Permanetter B, Baumann G, Dörner J, Schunack W, Blömer H.
    Journal: Agents Actions; 1985 Apr; 16(3-4):215-8. PubMed ID: 3160223.
    Abstract:
    First experiences in man indicate, that even in catecholamine-insensitive congestive cardiomyopathy a considerable improvement of myocardial function can be attained by the H2-receptor agonist impromidine. In an isolated, pressure-volume work performing guinea-pig heart preparation cardiac effects of three histaminergic compounds (Na,5-dimethylhistamine (HC1)2, 5-ethyl-Na-methyl-histamine (HC1)2, Na,Na-dimethyl-histamine (HC1)2) were examined. Influences on function and myocardial oxygen consumption were compared to those obtained by impromidine. Dose-response curves for the histamine derivatives were 1.7-2.5 orders of magnitude right of the impromidine curves. Maximal inotropic stimulation was greater for Na,5-dimethyl-histamine (HC1)2 than for impromidine. All compounds exhibited a high chronotropic effect and, at high concentrations, a net coronary dilating effect.
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