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  • Title: [Function of the membrane lipids of the heart sarcoplasmic network in izadrin myocarditis studied by using a pyrene probe].
    Author: Lyzlova LV, Persianova VR, Antipenko AE.
    Journal: Biull Eksp Biol Med; 1985 Jun; 99(6):674-7. PubMed ID: 3160411.
    Abstract:
    The fluorescent hydrophobic pyrene probe was employed to study the viscosity of membrane lipids of rat heart sarcoplasmic reticulum in isoproterenol myocarditis. During pyrene incorporation into the reticulum obtained from the affected myocardium, the increase in the microviscosity occurred at lower temperatures and more rapidly both in "bound" and "free" membrane lipids as compared with normal. The increase of the viscosity of the reticulum membranes in isoproterenol myocarditis was accompanied by a lowering of the activity of Ca, Mg-ATPase of the sarcoplasmic reticulum coupled with an elevation of the content of lipid peroxidation products.
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