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  • Title: [Phenotype of thymocyte populations in C57BL/Ka mice during the development of radiation-induced lymphomas].
    Author: Rongy AM, Greimers R, Defresne MP, Boniver J.
    Journal: C R Seances Soc Biol Fil; 1985; 179(2):265-70. PubMed ID: 3160447.
    Abstract:
    In C57BL/Ka mice, irradiated with 4 weekly X-ray doses of 1,75 Gy, the phenotype of thymocyte populations was analyzed with monoclonal antibodies, lectins and flow cytometry. Four successive phases were defined: a) early after irradiation, a depletion of radiosensitive cortical thymocytes with a relative enrichment for radioresistant medullary type cells; b) a regeneration phase, during which thymocytes express the cortical immature phenotype; c) a third period, with a relative increase of a population with medullary phenotype; d) a late phase, during which thymocytes with the same phenotype as lymphoma cells accumulate.
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