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  • Title: Natural Host-Induced Gene Silencing Offers New Opportunities to Engineer Disease Resistance.
    Author: Hou Y, Ma W.
    Journal: Trends Microbiol; 2020 Feb; 28(2):109-117. PubMed ID: 31606358.
    Abstract:
    RNA silencing is an essential gene-regulation mechanism in eukaryotic organisms. Guided by small RNAs (sRNAs) of 20-25 nt in length, RNA silencing broadly governs a wide range of biological processes. In addition to regulating endogenous gene expression and inhibiting viral infection, accumulating evidence suggests that sRNAs can also function as antimicrobial agents against nonviral pathogens and directly silence gene targets in invading pathogen cells. Here, we summarize current understanding of this host-induced gene silencing (HIGS) process as a defense mechanism during natural infection. Specific focuses will be on recent advancement in the sRNA executors of HIGS and their potential delivery mechanisms from the plant host to filamentous eukaryotic pathogens, including fungi and Phytophthora species. Implications of these new findings in the applications of HIGS as a tool for engineering disease resistance is discussed.
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