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  • Title: [Comparison of steroid metabolism in the testes and ovaries of 19-day-old rat embryos in culture in vitro].
    Author: Weniger JP, Zeis A.
    Journal: Reprod Nutr Dev (1980); 1985; 25(3):531-5. PubMed ID: 3161163.
    Abstract:
    Oestrone was the main oestrogen formed by the ovaries from both dehydroepiandrosterone and testosterone; oestradiol was only formed minimally. Much less oestrogen was formed in the testes, oestradiol being predominant. Androstenedione was the prevailing androgen in the ovaries and testosterone in the testes. These results obtained in vitro are probably also true in vivo. They show high aromatase activity in the ovaries. 17 beta-hydroxysteroid dehydrogenase favored androstenedione formation, and hence oestrone formation, in the ovaries and testosterone formation, and hence oestradiol formation, in the testes. Different results might be obtained at different embryonic stages.
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