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  • Title: Effect of acrylamide and related compounds on glycolytic enzymes of rat brain.
    Author: Tanii H, Hashimoto K.
    Journal: Toxicol Lett; 1985 Jul; 26(1):79-84. PubMed ID: 3161219.
    Abstract:
    The in vitro effect of acrylamide and its analogues on rat brain glycolytic enzymes was examined to elucidate the biochemical lesions responsible for the pathogenesis of acrylamide-induced neuropathy. All test compounds inhibited glyceraldehyde-3-phosphate dehydrogenase, irrespective of their neurotoxicity, and their inhibitory potency was a linear function of the rate constant with reduced glutathione. Phosphofructokinase was also inhibited by some of the test compounds, independently of their neurotoxicity. The rate-limiting enzymes in glycolysis, hexokinase and pyruvate kinase, were not inhibited by acrylamide.
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