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  • Title: Carbon-fibre versus Marlex mesh in the repair of experimental abdominal wall defects in rats.
    Author: Cameron AE, Taylor DE.
    Journal: Br J Surg; 1985 Aug; 72(8):648-50. PubMed ID: 3161576.
    Abstract:
    Large abdominal wall defects were created in Porton-Wistar rats and either left unrepaired (9 rats), or repaired with polypropylene (Marlex) mesh (11 rats), or with an open darn of filamentous carbon (11 rats). A further ten animals had a simple midline skin incision. At 5 months there were gross hernias in the unrepaired animals. Neither repair had resulted in gross recurrence although four of the carbon-repaired animals had bulges through the open weave. Tensiometry of the excised abdominal wall showed no difference in the strength of the two repairs. However, microscopy showed a striking difference-the Marlex had induced a chronic inflammatory response with disorganized collagen, whereas the carbon was not only well-tolerated but acted as a scaffold for well-organized and orientated collagen.
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