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  • Title: Dilution is not the solution: acute hemolytic transfusion reaction after ABO-incompatible pooled platelet transfusion.
    Author: Guarente J, Harach M, Gould J, Karp JK, Peedin AR.
    Journal: Immunohematology; 2019 Sep; 35(3):91-94. PubMed ID: 31621366.
    Abstract:
    The short shelf life of platelets makes providing ABO-compatible platelets a challenge, and many institutions issue ABO-incompatible platelets when compatible units are not available. It is presumed that ABO antibodies that exist in donor plasma are diluted when platelets from multiple donors are combined to make a pooled product for transfusion. We present a case of a hemolytic transfusion reaction in a 73-year-old man with myelodysplastic syndrome who received an ABO-incompatible pooled platelet unit. This case report demonstrates that the dilution theory is not always true for pooled platelet units, and any patient receiving ABO-incompatible platelet transfusions must be closely monitored for potential hemolytic transfusion reactions.
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