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  • Title: Analysis of bovine leukemia virus integration sites in cattle under 3 years old with enzootic bovine leukosis.
    Author: Maezawa M, Inokuma H.
    Journal: Arch Virol; 2020 Jan; 165(1):179-183. PubMed ID: 31624916.
    Abstract:
    In the present study, we analyzed bovine leukemia virus (BLV) integration sites in under 3 years old with enzootic bovine leukosis (EBL) cattle and compared these to 30 cattle over 3 years old with EBL. BLV proviruses were integrated near CpG islands and into long interspersed nuclear elements more frequently in EBL cattle under 3 years old than in those over 3 years old. These results suggest that cattle under 3 years old with EBL have different BLV provirus integration sites from those of cattle over 3 years old with EBL, and the BLV provirus integration site may represent one factor contributing to early onset of EBL.
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