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  • Title: Antibiotic sensitivity and clinical outcomes in staphylococcal scalded skin syndrome.
    Author: Wang Z, Feig JL, Mannschreck DB, Cohen BA.
    Journal: Pediatr Dermatol; 2020 Jan; 37(1):222-223. PubMed ID: 31626359.
    Abstract:
    Staphylococcal scalded skin syndrome causes widespread skin denudation primarily in infants < 1 year old. Selection of empiric therapy is complicated by rising rates of antibiotic resistance in community-acquired staphylococcal infections. Consistent with a previous study, this retrospective review found that SSSS-associated isolates were more likely to be clindamycin-resistant and less likely to be methicillin-resistant compared to overall staphylococcal infections. We favor cephalosporins and penicillinase-resistant penicillins (eg, oxacillin) for empiric management of SSSS, with consideration of adding MRSA coverage in communities with high MRSA prevalence or failure to improve following several days of treatment.
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