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  • Title: [Relation between plasma Ara-C and intracellular Ara-CTP levels by intermediate dose and high dose Ara-C administration in the treatment of AML].
    Author: Yoshida T, Kobayashi K, Nakamura S, Ohtake S, Itoh K, Kanno M, Hirai J, Yasushi, Matsuda TT.
    Journal: Gan To Kagaku Ryoho; 1988 Apr; 15(4 Pt 1):625-30. PubMed ID: 3162669.
    Abstract:
    Plasma level of cytosine arabinoside (Ara-C) and intracellular cytosine arabinoside triphosphate (Ara-CTP) in peripheral blood and bone marrow were measured in 8 patients with non treated acute myelogenous leukemia. Ara-C was administered by 1 hr infusion (3 g/m2 and 500 mg/m2) and was followed for 12 hrs. The AUC of Ara-C in plasma following 3 g/m2 infusion were greater than the 500 mg/m2 (p less than 0.05). Intracellular Ara-CTP in peripheral blood following 3 g/m2 and 500 mg/m2 infusions were on the same level, after 1 hr. But AUC of intracellular Ara-CTP following 3 g/m2 infusion was greater than 500 mg/m2. There was a correlation between AUC of Ara-C in the peripheral blood (p less than 0.01). Intracellular Ara-CTP in the bone marrow and peripheral blood showed a similar level. Intracellular Ara-CTP in bone marrow was lower than in peripheral blood, however, there was no correlation between intracellular Ara-CTP in bone marrow and in peripheral blood.
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