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  • Title: Lissamine green staining in the clinical diagnosis of xerophthalmia.
    Author: Emran N, Sommer A.
    Journal: Arch Ophthalmol; 1979 Dec; 97(12):2333-5. PubMed ID: 316322.
    Abstract:
    Lissamine green staining of the conjunctiva, a new and widely heralded aid for diagnosing early xerophthalmia, was found to be a reasonably specific but inadequately sensitive test for practical use. While 82% of clinically normal children failed to show staining, so did 57% with night blindness, 29% with vitamin A responsive Bitot's spots, and, most significantly, 26% with severe, vitamin A related corneal involvement. The test also failed to distinguish vitamin A responsive "Bitot's spots" from nonresponsive ones.
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