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  • Title: The effects of quaternary ammonium chloride (alpha C12 DME AHCl) on enamel hardness and mineral loss under intra oral cariogenicity test conditions.
    Author: van Croonenburg EJ, Wöltgens JH, van der Laan H, Schepens E.
    Journal: J Biol Buccale; 1988 Mar; 16(1):41-5. PubMed ID: 3165093.
    Abstract:
    The effects of a quaternary ammonium compound; 2-hydroxy-ethyl-2-hydroxydodecyl-dimethyl-ammonium chloride (alpha C12 DMEAHCl) on enamel hardness and mineral loss in enamel slabs were studied under intra-oral cariogenicity test conditions. The quaternary ammonium compound without fluoride reduced enamel softening as well as the mineral loss from enamel significantly up to a depth of 100 microns from the surface. Moreover the Ca/P molar ratio of the treated enamel was comparable to untreated enamel controls. These findings suggest that the quaternary ammonium compound itself inhibits mainly demineralisation rather than remineralization under intra-oral cariogenicity test conditions.
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