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  • Title: A new role for vault RNA-TEP1 complexes in mRNA production in trypanosomes.
    Author: Kickhoefer VA.
    Journal: J Biol Chem; 2019 Oct 25; 294(43):15575-15576. PubMed ID: 31653772.
    Abstract:
    Vault RNAs, found in vault ribonucleoprotein complexes, are known to be one of many types of small noncoding RNAs (ncRNAs), but their specific function is not known. A new study identifies a small ncRNA from Trypanosome brucei as a vault RNA (vtRNA) based on sequence analysis and its association with the canonical vault component TEP1. Down-regulation of T. brucei vtRNA impairs mRNA splicing in a permeabilized cell system, suggesting new roles for these enigmatic biomolecules.
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