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  • Title: Eculizumab in post-transplant C3 glomerulonephritis caused by a C3 mutation
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    Author: Kim JS, Foster KW, Westphal SG.
    Journal: Clin Nephrol; 2020 Jan; 93(1):51-56. PubMed ID: 31661064.
    Abstract:
    C3 glomerulonephritis (C3GN) is a disorder of excess alternative complement activation leading to glomerular injury. Following kidney transplantation, C3GN has a high recurrence rate, and the overall prognosis is poor without treatment. However, treatment efficacy is highly variable. Eculizumab, a humanized monoclonal antibody that targets complement C5 to inhibit terminal complement activity, has emerged as a potential treatment option for C3G, although data regarding its clinical utility remains limited. In this report, we describe the successful use of eculizumab to treat a patient with recurrent post-transplant C3GN caused by a C3 gene gain-of-function mutation, and also review the published literature regarding the use of eculizumab for the treatment of recurrent C3 glomerulopathy.
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