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  • Title: Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers.
    Author: Madeira do O J, Foralosso R, Yilmaz G, Mastrotto F, King PJS, Xerri RM, He Y, van der Walle CF, Fernandez-Trillo F, Laughton CA, Styliari I, Stolnik S, Mantovani G.
    Journal: Nanoscale; 2019 Nov 28; 11(44):21155-21166. PubMed ID: 31663091.
    Abstract:
    Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that glycopolymers with a fine-tuned balance between hydrophilic sugar pendant units and relatively hydrophobic polymer backbones can act as single-chain targeted nanocarriers for low molecular weight hydrophobic molecules. Non-covalent complexes formed from poly(triazolyl methacrylate) glycopolymers and low molecular weight hydrophobic guest molecules were characterised through a range of analytical techniques - DLS, SLS, TDA, fluorescence spectroscopy, surface tension analysis - and molecular dynamics (MD) modelling simulations provided further information on the macromolecular characteristics of these single chain complexes. Finally, we show that these nanocarriers can be utilised to deliver a hydrophobic guest molecule, Nile red, to both soluble and surface-immobilised concanavalin A (Con A) and peanut agglutinin (PNA) model lectins with high specificity, showing the potential of non-covalent complexation with specific glycopolymers in targeted guest-molecule delivery.
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