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  • Title: Antiplasmodial Bis-Indole Alkaloids from the Bark of Flindersia pimenteliana.
    Author: Robertson LP, Lucantoni L, Avery VM, Carroll AR.
    Journal: Planta Med; 2020 Jan; 86(1):19-25. PubMed ID: 31663109.
    Abstract:
    Three new (1: -3: ) and 2 known (4: -5: ) bis-indole alkaloids were identified from the bark of Flindersia pimenteliana (Rutaceae). The structures of 1: -3: were elucidated on the basis of their (+)-HRESESIMS and 2D NMR spectroscopic data. Antiplasmodial activity for 1: -3: against chloroquine sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum is also reported, with IC50 values ranging from 0.96 to 2.41 µg/mL. These results expand our knowledge of the structure-activity relationships of potently antiplasmodial isoborreverine-type alkaloids, the bioactivity of which have recently attracted significant attention in the literature.
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