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  • Title: Efficacy of pefloxacin-fosfomycin in experimental endocarditis caused by methicillin-resistant Staphylococcus aureus.
    Author: Thauvin C, Lemeland JF, Humbert G, Fillastre JP.
    Journal: Antimicrob Agents Chemother; 1988 Jun; 32(6):919-21. PubMed ID: 3166360.
    Abstract:
    The efficacies of pefloxacin, fosfomycin, and both of these agents in combination against methicillin-resistant Staphylococcus aureus were assessed in a rat endocarditis model. The combination prevented emergence of the fosfomycin and pefloxacin resistance seen in 36 and 4%, respectively, of animals receiving either agent alone and was more effective than either agent in sterilizing cardiac vegetations.
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