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  • Title: Surgical treatment for osteosarcoma.
    Author: Springfield DS, Schmidt R, Graham-Pole J, Marcus RB, Spanier SS, Enneking WF.
    Journal: J Bone Joint Surg Am; 1988 Sep; 70(8):1124-30. PubMed ID: 3166461.
    Abstract:
    Fifty-three patients who had a high-grade osteosarcoma had either a limb-salvage resection or an amputation. They all received adjuvant therapy that consisted of administration of Adriamycin (doxorubicin) and whole-lung irradiation. At the time of follow-up, the surgical margin was assessed by examination of the surgical specimen. Each patient was followed for at least three years or until death. The data suggested that a wide surgical margin is adequate to control a primary osteosarcoma. When a wide surgical margin can be used and a functional limb can be salvaged, an amputation probably is not required.
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