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  • Title: Simultaneous High-Resolution Detection of Bioenergetic Molecules using Biomimetic-Receptor Nanopore.
    Author: Su Z, Wei Y, Kang XF.
    Journal: Anal Chem; 2019 Dec 03; 91(23):15255-15259. PubMed ID: 31665602.
    Abstract:
    A novel artificial receptor, heptakis-[6-deoxy-6-(2-hydroxy-3-trimethylammonion-propyl) amino]-beta-cyclomaltoheptaose, with similar functions of mitochondrial ADP/ATP carrier protein, was synthesized and harbored in the engineered α-HL (M113R)7 nanopore, forming a single-molecule biosensor for sensing bioenergetic molecules and their transformations. The strategy significantly elevates both selectivity and signal-to-noise, which enables simultaneous recognition and detection of ATP, ADP, and AMP by real-time single-molecule measurement.
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