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  • Title: Genetic polymorphisms of IL-10, IL-18 and IL12B are associated with risk of non-small cell lung cancer in a Chinese Han population.
    Author: Zhang W, Dang S, Zhang G, He H, Wen X.
    Journal: Int Immunopharmacol; 2019 Dec; 77():105938. PubMed ID: 31670094.
    Abstract:
    PURPOSE: IL-10, IL-18 and IL-12 are reported to participate in the inflammation process. The potential influences of IL-10, IL-18 and IL-12 polymorphisms on non-small cell lung cancer (NSCLC) risk were explored in this study. METHODS: Six candidate SNPs from 500 NSCLC patients and 500 controls were genotyped. The correlation between the SNPs and NSCLC risk was evaluated by logistic regression analysis. RESULTS: Comparisons of the allele and genotype frequencies showed that five SNPs were correlated with NSCLC risk. The minor allele 'G' of IL-18 rs5744256 and rs1834481 and IL-10 rs3021094 was correlated with a decreased risk of NSCLC (p < 0.05). In contrast, the minor allele 'T' of IL-18 rs5744224 and the minor allele 'G' of IL-12B rs3212227 were correlated with an increased risk of NSCLC (p < 0.05). By genetic model analysis, we found that rs5744256 and rs1834481 were associated with a decreased risk of NSCLC under dominant and log-additive models (p < 0.05). Rs3021094 was correlated with a decreased risk of NSCLC under all three models (p < 0.05). In contrast, rs5744224 was associated with an increased risk of NSCLC under the recessive model (p = 0.005), and rs3212227 was associated with an increased risk of NSCLC under all three models (p < 0.05). Finally, the GGA haplotype of rs5744256, rs1834481 and rs5744224 and the GT haplotype of rs3021094 and rs3790622 were associated with a decreased risk of NSCLC (p < 0.05). CONCLUSION: Our results provided new candidate SNPs for the prediction and prevention of NSCLC.
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