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  • Title: Associations of Prenatal Dietary Inflammatory Potential with Childhood Respiratory Outcomes in Project Viva.
    Author: Hanson C, Rifas-Shiman SL, Shivappa N, Wirth MD, Hebert JR, Gold D, Camargo CA, Sen S, Sordillo JE, Oken E, Litonjua AA.
    Journal: J Allergy Clin Immunol Pract; 2020 Mar; 8(3):945-952.e4. PubMed ID: 31678301.
    Abstract:
    BACKGROUND: Inflammation during pregnancy may be a factor in the developmental programming of asthma and wheeze in childhood. OBJECTIVE: To examine associations of inflammatory potential of prenatal diet with respiratory outcomes in early childhood and midchildhood. METHODS: Among 1424 mother-child pairs in Project Viva, a prebirth cohort, we examined associations of Dietary Inflammatory Index (DII®) (first trimester, second trimester, and average of first and second trimesters) scores in relation to ever asthma and wheezing in the past year (early childhood and midchildhood); current asthma and lung function (midchildhood), and wheeze trajectory during 1 to 9 years. We used multivariable linear and logistic regression modeling, adjusting for relevant confounders. RESULTS: In a fully adjusted analysis, a more proinflammatory diet was associated with an early versus never wheeze trajectory (first- and second-trimester average fourth vs first quartile: odds ratio, 1.89; 95% CI, 1.14-3.13). A more proinflammatory diet during pregnancy also was associated with lower forced expiratory flow (forced expiratory flow at 25%-75%) in midchildhood (first- and second-trimester average fourth vs first quartile: β, -132 mL; 95% CI, -249 to -14). Results were evident for first-, but not second-, trimester DII and wheeze trajectory and midchildhood forced expiratory flow at 25% to 75%. Other child respiratory outcomes, including ever asthma, were not related to any DII measure during pregnancy. CONCLUSIONS: Proinflammatory diet during pregnancy is associated with wheeze trajectory during early childhood and decrements in small airways caliber in midchildhood, but not other respiratory outcomes in the offspring.
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