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  • Title: In vitro interaction between cefotetan and aminoglycosides on Staphylococcus aureus and coagulase negative staphylococci, both methicillin-susceptible and -resistant.
    Author: Stefani S, Debbia E, Schito GC, Nicoletti G.
    Journal: Chemioterapia; 1988 Jun; 7(3):151-5. PubMed ID: 3168069.
    Abstract:
    The authors have evaluated the behavior of the interaction between cefotetan, a new cephalosporin with long acting resistance to the action of beta-lactamases, and gentamicin, amikacin and netilmicin against methicillin-susceptible and -resistant staphylococci. In 65.8% of the cases, drug combinations showed synergic effects. Results were subdivided for susceptibility or resistance to the drugs used in combination. In general, when both drugs were tested against methicillin-susceptible strains the results showed synergism.
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