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  • Title: Different effects of norepinephrine and KCl on the cytosolic Ca2+-tension relationship in vascular smooth muscle of rat aorta.
    Author: Karaki H, Sato K, Ozaki H.
    Journal: Eur J Pharmacol; 1988 Jul 07; 151(2):325-8. PubMed ID: 3169125.
    Abstract:
    Norepinephrine and KCl induced a concentration-dependent increase in the cytosolic Ca2+ level [( Ca2+]cyt) measured either by intracellular fura 2-Ca2+ fluorescence or by 45Ca2+ uptake. Muscle contraction in isolated rat aortic strips was also increased although a greater contraction was induced by norepinephrine than by KCl at the same [Ca2+]cyt. This result suggests that the contraction of vascular smooth muscle is regulated by [Ca2+]cyt and also by other factor(s).
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