These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: General Synthesis of N-Alkylation of Amines with Secondary Alcohols via Hydrogen Autotransfer.
    Author: Subaramanian M, Midya SP, Ramar PM, Balaraman E.
    Journal: Org Lett; 2019 Nov 15; 21(22):8899-8903. PubMed ID: 31691555.
    Abstract:
    Direct catalytic N-alkylation of amines with secondary alcohols via hydrogen autotransfer (HA) strategy is very challenging and has been scarcely reported, even under precious metal catalysis. Herein, an efficient N-alkylation of amines, including benzylamines using secondary alcohols as alkylating agents, is reported. This reaction is catalyzed by a molecularly defined NNN-Ni(II) pincer complex, and the reaction operates under mild, benign conditions. Various substrates and functional groups were tolerated. Preliminary mechanistic studies suggest that the N-alkylation reaction proceeds via a hydrogen autotransfer mechanism.
    [Abstract] [Full Text] [Related] [New Search]