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  • Title: A major role for protein kinase C in calcium-activated exocytosis in permeabilised adrenal chromaffin cells.
    Author: Burgoyne RD, Morgan A, O'Sullivan AJ.
    Journal: FEBS Lett; 1988 Sep 26; 238(1):151-5. PubMed ID: 3169247.
    Abstract:
    The role of endogenously activated protein kinase C in calcium-activated exocytosis was examined in digitonin-permeabilised bovine adrenal chromaffin cells. Protein kinase C activity was reduced by down-regulation following long-term treatment with PMA or by using the inhibitor sphingosine. Both treatments resulted in a substantial reduction in catecholamine secretion elicited by micromolar calcium, indicating that endogenous activation of protein kinase C is a major requirement for calcium-activated exocytosis in chromaffin cells.
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