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  • Title: Ontogeny of mitogen responsive lymphocytes in the bovine fetus.
    Author: Jensen J, Rubino M, Yang WC, Cooley AJ, Schultz RD.
    Journal: Dev Comp Immunol; 1988; 12(3):685-92. PubMed ID: 3169358.
    Abstract:
    Bovine fetal lymphocytes were examined for their ability to respond to the mitogens phytohemagglutinin (PHA), Concanavalin A (ConA) and pokeweed mitogen (PWM) in the lymphocyte blastogenesis test (LBT). PHA-, Con A- and PWM-responsive lymphocytes appeared simultaneously at 75-80 days of gestation. The response increased with age of the fetus until, by 120 days of gestation, the response to PHA, Con A and PWM of many fetuses was in the range of values obtained with lymphocytes from normal adult cattle.
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