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  • Title: Sesquiterpenes and diterpenes from Euphorbia thymifolia.
    Author: Liu JL, Yu M, Liao HB, Liu T, Tan YH, Liang D, Zhang GJ.
    Journal: Fitoterapia; 2019 Nov; 139():104408. PubMed ID: 31698058.
    Abstract:
    One new pseudoguaianolide (1), one new megastigmane (6), and one new ent-abietane diterpene (9), together with seven known compounds (2-5, 7, 8, and 10) were isolated from the aerial parts of Euphorbia thymifolia. The structures of the new compounds and their relative configurations were determined by spectroscopic data analysis. The absolute configurations of compounds 1, 6, and 9 were determined by single-crystal X-ray crystallographic analysis, modified Mosher's method and calculated ECD experiment, respectively. All compounds were tested for their inhibitory effects against LPS-induced NO production in BV-2 microglial cells, and pseudoguaianolides (1-5) showed significant activity with IC50 values of 0.41-15.32 μM.
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