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  • Title: Bioavailability of various vitamin E compounds in sheep.
    Author: Hidiroglou N, McDowell LR, Pastrana R.
    Journal: Int J Vitam Nutr Res; 1988; 58(2):189-97. PubMed ID: 3170092.
    Abstract:
    Seventeen crossbred yearling wethers were randomly allotted to four dietary groups that consisted of 400 IU/day/sheep either of (1) dl-alpha-tocopherol (five sheep), (2) dl-alpha-tocopherol acetate (five sheep), (3) d-alpha-tocopherol (four sheep) or (4) d-alpha-tocopherol acetate (three sheep). Blood samples were taken at day 0 and then at frequent intervals for alpha-tocopherol determination. At the end of the 28-day experiment, animals were killed and various tissues sampled. Higher concentrations of alpha-tocopherol were observed in tissues of sheep fed d-alpha-tocopherol than the other tocopherol forms. In sheep fed d-alpha-tocopherol, the most important index of bioavailability, the area under the plasma alpha-tocopherol time curve (AUC), was larger as compared to other forms of vitamin E supplementation. Identification of alpha-tocopherol was confirmed by gas-chromatography/mass spectrometry.
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