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  • Title: Evaluation of PAP in EGFR Mutational Testing in Advanced NSCLC: a Comparative Study.
    Author: Jinliang C, Yang X, Xiaoyan X, Yudong S, Xinyue W, Zhaoting M, Li L, Ning S, Hua G, Dingzhi H, Lun Z, Peng C.
    Journal: Clin Lab; 2019 Nov 01; 65(11):. PubMed ID: 31710424.
    Abstract:
    BACKGROUND: EGFR mutational testing is crucial for advanced non-squamous NSCLC. PAP is a sensitive and selective method to detect rare mutations. METHODS: Eighty-five patients with non-squamous NSCLC were enrolled in this study. A set of paired plasma samples from each patient were collected and detected by PAP and ARMS. RESULTS: Of 85 paired samples, 78.8% (67/85) presented the same mutational status by the two methods. There was no statistically significant difference between the mutation frequencies in plasma samples detected with PAP and ARMS (p = 0.096). CONCLUSIONS: PAP technology appears to be an alternative choice with relatively high sensitivity for the detection of plasma EGFR mutations.
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