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  • Title: Bone Formation of Titanium Implant Surfaces Treated with Submicron Poly(lactide-co-glycolide)/Recombinant Human Transforming Growth Factor- β2 Particles by the Electrospray Method: An In Vivo Study.
    Author: Kim J, Kim SK, Heo SJ, Koak JY.
    Journal: Int J Oral Maxillofac Implants; 2019; 34(6):1404-1412. PubMed ID: 31711082.
    Abstract:
    PURPOSE: This study evaluated the effect of anodized titanium implants coated with submicron-sized poly(lactide-co-glycolide) (PLGA)/recombinant human transforming growth factor- β2 (rhTGF- β2) particles via electrospray on osseointegration in an in vivo model. MATERIALS AND METHODS: An experimental group of anodized titanium implants coated with submicron PLGA/rhTGF-β2 particles by electrospray was compared topographically and histomorphometrically to noncoated anodized implants. Forty-eight anodized titanium implants were inserted into the tibias of 12 New Zealand rabbits. The histomorphometric specimens were prepared after sacrificing at 3 and 6 weeks after implant placement. Bone-to-implant contact percentage (BIC%) and bone area percentage (BA%) were calculated. The surface roughness and histomorphometric values were statistically analyzed, with a P value < .05 defined as statistically significant. RESULTS: The implant surfaces showed a uniform submicron-sized coating of PLGA/rhTGF-β2 particles. There was no significant difference in surface roughness between the groups. Both BIC% and BA% of the three best consecutive threads in the experimental group (3 weeks postplacement) were significantly higher than those of the control group (P = .045 and P = .048, respectively), whereas only the BIC% of the three best consecutive threads of the experimental group (6 weeks postplacement) was higher than that of the control group (P = .033). None of the groups tested showed any statistically significant differences in these metrics along the total length of the implant. CONCLUSION: Within the limitations of this study, coating rhTGF-β2 on implants with the help of PLGA carriers by electrospray may have enhanced osseointegration during the early stage of implant healing period in in-vivo rabbit tibia model.
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