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  • Title: Alcohol intake during pregnancy and timing of puberty in sons and daughters: A nationwide cohort study.
    Author: Brix N, Lauridsen LLB, Ernst A, Olsen J, Henriksen TB, Ramlau-Hansen CH.
    Journal: Reprod Toxicol; 2020 Jan; 91():35-42. PubMed ID: 31711902.
    Abstract:
    We explored whether maternal alcohol intake in early pregnancy is associated with pubertal timing in sons and daughters. In total, 15,819 children, born 2000-2003 within the Danish National Birth Cohort, gave half-yearly, self-reported information on pubertal development (Tanner stages, voice break, first ejaculation, menarche, acne, and axillary hair) from 11 years during 2012-2018. Information on maternal average alcohol intake in first trimester and binge drinking episodes (intake of ≥5 drinks on the same occasion) in first trimester was self-reported by mothers during pregnancy. Average alcohol intake of 5+ weekly drinks in first trimester was not associated with pubertal timing in sons (with no alcohol intake as the reference). A tendency towards earlier pubertal timing was observed in daughters (-2.0 (95 % confidence interval: -4.2, 0.3) months) when combining the estimates for all pubertal milestones. Binge drinking was not associated with pubertal timing in neither sons nor daughters.
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