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  • Title: Organocatalytic Asymmetric Conjugate Addition of Aldehydes to Maleimides and Nitroalkenes in Deep Eutectic Solvents.
    Author: Torregrosa-Chinillach A, Sánchez-Laó A, Santagostino E, Chinchilla R.
    Journal: Molecules; 2019 Nov 09; 24(22):. PubMed ID: 31717507.
    Abstract:
    A chiral primary amine-salicylamide is used as an organocatalyst for the enantioselective conjugate addition of α,α-disubstituted aldehydes to maleimides and nitroalkenes. The reactions are performed in deep eutectic solvents as reaction media at room temperature, leading to the corresponding adducts with enantioselectivities up to 88% (for maleimides) and 80% (for nitroalkenes). Catalyst and solvent can be recovered and reused.
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