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Title: [Albumin-to-bilirubin scores for assessing the prognosis in autoimmune hepatitis-related cirrhosis].
Author: Song Y, Yang H, Lin L, Jiang K, Liu WT, Wang BM, Lin R.
Journal: Zhonghua Gan Zang Bing Za Zhi; 2019 Oct 20; 27(10):772-776. PubMed ID: 31734991.
Abstract:
Objective: To investigate the prognostic value of albumin-to-bilirubin scores in the assessment of autoimmune hepatitis-related cirrhosis. Methods: The receiver operating characteristic curve was used to evaluate the accuracy of ALBI, Child-Pugh and model for end-stage liver disease (MELD) for prognosis prediction. Survival analysis was performed according to the ALBI classification. Spearman correlation analysis was performed on the ALBI score and the Child-Pugh score. Survival curves were plotted by Kaplan-Meier method, and Log-rank method was used to compare the survival difference curves between different groups. Results: 149 patients were recruited in the study. The ROC analysis showed that the ALBI scores (0.861, 0.826, 0.779, 0.744)was superior to Child-Pugh scores(0.703, P = 0.006; 0.672, P < 0.001; 0.613, P < 0.001; 0.583, P < 0.001)and MELD score(0.774, P = 0.031; 0.731, P = 0.007; 0.669, P < 0.001; 0.631, P < 0.001) for predicting 6, 12, 24, and 36 months mortality. Patients with ALBI grade 3 had a significantly lower survival rate than those with ALBI grade1 and grade 2. Conclusion: ALBI score may be useful to evaluate the long-term prognosis of patients with autoimmune hepatitis-related cirrhosis. 目的： 探讨白蛋白-胆红素（ALBI）评分在自身免疫性肝炎肝硬化预后评估中的价值。 方法： 采用受试者工作特征曲线评估ALBI、Child-Pugh和终末期肝病模型评分对预后预测的准确性。根据ALBI分级进行生存分析。对ALBI评分及Child-Pugh评分进行Spearman相关分析。采用Kaplan-Meier法绘制生存曲线，用Log-rank方法比较不同组间生存曲线差异。 结果： 共纳入149例患者。受试者工作曲线显示ALBI评分（0.861，0.826，0.779，0.744）对6、12、24、36个月病死预测的准确性高于Child-Pugh评分（0.703，P = 0.006；0.672，P < 0.001；0.613，P < 0.001；0.583，P < 0.001）和终末期肝病模型评分（0.774，P = 0.031；0.731，P = 0.007；0.669，P < 0.001；0.631，P < 0.001）。ALBI 3级患者生存率显著低于ALBI 1级和2级患者。 结论： ALBI评分可用于评价自身免疫性肝炎肝硬化患者的远期预后。.

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