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  • Title: Neonatal dopamine depletions spare lateral hypothalamic stimulation reward in adult rats.
    Author: Stellar JR, Waraczynski M, Bruno JP.
    Journal: Pharmacol Biochem Behav; 1988 Jun; 30(2):365-70. PubMed ID: 3174768.
    Abstract:
    Previous research has shown that adult rats sustaining near-total depletions of striatal dopamine (DA) as neonates exhibit few of the profound deficits in ingestion and sensory-motor behavior seen in comparably lesioned adults. This study extends these findings to another realm of DA-related behavior, reward function. In a rate-frequency curve-shift measurement paradigm, reward effectiveness of lateral hypothalamic brain stimulation was shown to be normal in adult rats depleted of brain DA as neonates. However, impairments were seen in rapid-initiation operant performance. Neonatally DA-depleted rats were also shown to be subsensitive to the DA receptor antagonist pimozide, suggesting that activity within undamaged DA neurons is not necessary for the elicitation of hypothalamic self-stimulation reward.
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