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  • Title: Controllable growth of Au nanostructures onto MoS2 nanosheets for dual-modal imaging and photothermal-radiation combined therapy.
    Author: Liu T, Shen S, Huang Y, Zhang X, Lai Z, Tran TH, Liu Z, Cheng L.
    Journal: Nanoscale; 2019 Dec 21; 11(47):22788-22795. PubMed ID: 31748768.
    Abstract:
    Multifunctional theranostic nanoagents are attractive to realize comprehensive imaging and effective treatment of tumours. Herein, a novel strategy is developed to controllably guide the epitaxial growth of gold nanostructures onto MoS2 nanosheets. The as-prepared MoS2-Au nanostructures (MA) manifest an enhanced near-infrared (NIR) absorbance with strong photostability. After modification, the obtained MA-PEG shows strong X-ray attenuation and photothermal conversion ability, promising for CT and photoacoustic imaging with an enhanced intensity in tumours. Moreover, in vivo photothermal and radiation therapy with MA-PEG achieves synergistic tumour treatment efficiency through hyperthermia elevated oxygenation level and sensitized radiation therapy. This work illustrates the development of a unique MA nanostructure with enhanced NIR absorbance and strong photoelectric absorbance as a multifunctional theranostic agent with great potential for dual-modal imaging-guided photothermal-radiation therapy of cancer.
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