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  • Title: Diterpenoids from Euphorbia neriifolia and Their Related Anti-HIV and Cytotoxic Activity.
    Author: Li JC, Feng XY, Liu D, Zhang ZJ, Chen XQ, Li RT, Li HM.
    Journal: Chem Biodivers; 2019 Dec; 16(12):e1900495. PubMed ID: 31755643.
    Abstract:
    Fifteen diterpenoids (1-15), including three undescribed ones with ent-atisane skeleton, eupnerias G-I (1-3), were obtained from Euphorbia neriifolia. Compounds 1-3 were established through comprehensive spectroscopic analysis. Compounds 4 and 5 exhibited obvious anti-HIV-1 effect, and their EC50 were 6.6±3.2 and 6.4±2.5 μg mL-1 , respectively. Compound 6 exhibited moderate cytotoxicity on HepG2 and HepG2/Adr cells with IC50 at 13.70 and 15.57 μm, respectively. In addition, compound 15 exhibited significant cytotoxicity on HepG2 cell lines (IC50 =0.01 μm), while it did not show any cytotoxicity against HepG2/Adr cell lines.
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