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  • Title: Anti-inflammatory steroids from the fruits of Artocarpus heterophyllus.
    Author: Liu YY, Wang T, Yang RX, Tang HX, Qiang L, Liu YP.
    Journal: Nat Prod Res; 2021 Sep; 35(18):3071-3077. PubMed ID: 31755785.
    Abstract:
    A phytochemical study on the fruits of Artocarpus heterophyllus caused the isolation of a previously undescribed steroid, artoheterophoid (1), together with seven known analogues (2 - 8). The chemical structure of 1 was elucidated on the basis of comprehensive spectroscopic methods and the known compounds (2 - 8) were identified by comparing their spectroscopic data with those reported in the literatures. All known compounds (2-8) were separated from A. heterophyllus for the first time. All isolated compounds (1-8) were assessed for their anti-inflammatory activities in vitro by measuring the inhibitory effect against nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells. Compounds 1-8 displayed remarkable inhibitory effects against NO production with the IC50 values in the range of 0.72 ± 0.07 to 5.93 ± 0.12 μM.
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