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  • Title: Healthy live births after mosaic blastocyst transfers with the use of next-generation sequencing.
    Author: Liu YL, Yu TN, Chen CH, Wang PH, Chen CH, Tzeng CR.
    Journal: Taiwan J Obstet Gynecol; 2019 Nov; 58(6):872-876. PubMed ID: 31759546.
    Abstract:
    OBJECTIVE: To determine whether transfer of high-mosaicism (≥50%) embryos can result in healthy newborns. CASE REPORT: Two embryos resulting from controlled ovarian stimulation (COS) in Patient one, 41 years of age (y/o), underwent preimplantation genetic testing for aneuploidy (PGT-A), which demonstrated that one was mosaic (68%) and the other aneuploid; the mosaic embryo was transferred. Amniocentesis at 18 weeks of gestational age (GA) revealed a normal 46, XY karyotype. A phenotypically normal boy was delivered at 39 and 5/7 weeks of GA. For Patient two, 39 (y/o), nine embryos obtained after COS underwent PGT-A, indicating one euploid, four mosaic, and four aneuploid embryos. One euploid and one mosaic (50%) embryo were transferred, resulting in a twin pregnancy. Amniocentesis at 18 weeks of GA showed both fetuses had normal 46, XY karyotypes. Two phenotypically normal boys were delivered at 37 2/7 weeks of GA. CONCLUSION: Transfer of high-mosaicism embryos selected using current techniques can result in healthy euploid newborns. Amniocentesis suggested that mosaic embryos can be self-corrected before 18 weeks of GA.
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