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  • Title: A new "turn-on" fluorescence probe based on hydrazine-triggered tandem reaction.
    Author: Xu W, Li X, Han M, Zhou T, Yang Y, Li W.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2020 Mar 05; 228():117754. PubMed ID: 31759882.
    Abstract:
    Hydrazine is extremely harmful to the human body. The leakage of hydrazine is liable to cause potential safety hazards. Here, we reported a new fluorescence probe based on the tandem reaction. The hydrazine-triggered hydrazinolysis-cyclization resulted in the formation of the iminocoumarin. The fluorescence intensity at 522 nm of the probe increased after the reaction with hydrazine. There was a linear relationship between the fluorescence intensity and the concentration of hydrazine (0.14-120.00 μM). The LOD of the probe to N2H4 was 1.36 ppb. Notably, the probe could detect hydrazine in BT474 cells and tap water.
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