These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Association between IL-1A (-889C/T) polymorphism and susceptibility of chronic periodontitis: A meta-analysis.
    Author: Feng X, Liu J.
    Journal: Gene; 2020 Mar 01; 729():144227. PubMed ID: 31759990.
    Abstract:
    OBJECTIVE: The purpose of this study was to investigate the association between IL-1A (-889C/T, rs1800587) polymorphism and susceptibility of chronic periodontitis. METHODS: A systematic literature search was carried out in the databases updated on July 1, 2019, including PubMed, Embase, Cochrane Library and Web of Science. Through STATA 14.0 software, the association between IL-1A (-889C/T) polymorphism and susceptibility of chronic periodontitis was calculated by pooled odds rations (ORs) and 95% confidence intervals (CIs). Harbord test was used for the publication bias. RESULTS: The results of overall meta-analysis revealed that IL-1A (-889C/T) polymorphism was associated with the susceptibility of chronic periodontitis among all the genetic models, including allele contrast [T vs. C, OR (95% CI): 1.297 (1.038-1.622), P = 0.022], dominant model [TT + CT vs. CC, OR (95% CI): 1.337 (1.015-1.761), P = 0.039], recessive model [TT vs. CC + CT, OR (95% CI): 1.453 (1.138-1.856), P = 0.003], and codominant model [TT vs. CC, OR (95% CI): 1.555 (1.187-2.038), P = 0.001; CT vs. CC, OR (95% CI): 2.559 (1.245-5.260), P = 0.011]. The results of subgroup analyses indicated that IL-1A (-889C/T) polymorphism was closely related to the susceptibility of chronic periodontitis in African population [T vs. C, OR (95% CI): 1.277 (1.039-1.571), P = 0.020; TT + CT vs. CC, OR (95% CI): 1.357 (1.061-1.735), P = 0.015; TT vs. CC, OR (95% CI): 1.599 (1.115-2.292), P = 0.011], in European population [TT vs. CC + CT, OR (95% CI): 1.645 (1.112-2.435), P = 0.013; TT vs. CC, OR (95% CI): 1.639 (1.044-2.574), P = 0.032] and in American population [CT vs. CC, OR (95% CI): 6.404 (3.000-13.669), P < 0.001]. CONCLUSIONS: IL-1A (-889C/T) polymorphism is associated with the susceptibility of chronic periodontitis in African, European and American populations according to the currently available evidence.
    [Abstract] [Full Text] [Related] [New Search]