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  • Title: Lipase is associated with deltamethrin resistance in Culex pipiens pallens.
    Author: Hu HX, Zhou D, Ma L, Shen B, Sun Y, Zhu CL.
    Journal: Parasitol Res; 2020 Jan; 119(1):23-30. PubMed ID: 31760499.
    Abstract:
    The wide application of pyrethroids has led to the rapid development of insecticide resistance in mosquitoes, leading to a rise in mosquito-borne diseases. We previously identified five differentially expressed lipase family genes upon evaluating the transcriptomes of deltamethrin-resistant and deltamethrin-susceptible strains of Culex pipiens pallens. Herein, the gene expression levels were verified by quantitative real-time PCR, and two lipase family genes, lipase A and pancreatic triacylglycerol lipase A, were chosen for further investigations. Using cell viability assays and Centers for Disease Control and Prevention bottle bioassays, lipase A was found to increase the resistance of mosquitoes against deltamethrin both in vitro and in vivo. Our findings indicate that lipase A is involved in conferring deltamethrin resistance in Cx. pipiens pallens.
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