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  • Title: Trikoramide A, a Prenylated Cyanobactin from the Marine Cyanobacterium Symploca hydnoides.
    Author: Phyo MY, Ding CYG, Goh HC, Goh JX, Ong JFM, Chan SH, Yung PYM, Candra H, Tan LT.
    Journal: J Nat Prod; 2019 Dec 27; 82(12):3482-3488. PubMed ID: 31763840.
    Abstract:
    A new cyclic decapeptide, trikoramide A (1), has been isolated from samples of the marine cyanobacterium Symploca hydnoides, collected from Bintan Island, Indonesia. Trikoramide A (1) is a C-prenylated cyclotryptophan-containing cyanobactin. Its planar structure was deduced by 1D and 2D NMR spectroscopy as well as HR-MS/MS data. In addition, its absolute configuration was determined by Marfey's method and 2D NOESY NMR spectroscopic analysis. Compound 1 possessed cytotoxicity against the MOLT-4 and AML2 cancer cell lines with IC50 values of 4.8 and 8.2 μM, respectively.
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