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  • Title: [Determination of clearance for urea-controlled hemodialysis].
    Author: Ahrenholz P, Holtz M, Falkenhagen D, Klinkmann H.
    Journal: Z Urol Nephrol; 1988 Jul; 81(7):455-66. PubMed ID: 3176721.
    Abstract:
    Through a simple variant of the urea model the qualitative influence of the dialyzer-clearance on the individual dialysis guidance is elucidated. Realization of the respective Kdtd/V-value require an exact knowledge of the in-vivo-urea-clearance of all available dialyzer types and their manipulation with the aid of blood flow. The theoretical connections are explained and possible parameters affecting the in-vivo-clearance are discussed. The results concerning the dependence of urea-clearance on the blood flow are presented in an urea-guided dialysis patient pool for all in the GDR customary in the trade or temporary available dialyzers. It is shown, that in MLW-dialyzers an influence on the urea-clearance about the blood flow is small because of their relatively thick-walled membrane. Therefore, the development of dialysis membranes with superior diffusible permeability is necessary.
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