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  • Title: Premature rupture of fetal membranes changes in collagen type.
    Author: al-Zaid NS, Gumaa KA, Bou-Resli MN, Ibrahim ME.
    Journal: Acta Obstet Gynecol Scand; 1988; 67(4):291-5. PubMed ID: 3176950.
    Abstract:
    Collagen from the chorioamnion units from premature and term pregnancies was solubilized by limited pepsin digestion and subjected to SDS-PAG electrophoresis. Collagen types were quantitated by densitometry. It was found that collagen type III decreases and collagen type V tends to increase as gestational age advances. Investigating the relative abundance of collagen types at various membrane sites from term pregnancies revealed that type V decreases in the amnion as the rupture site is approached. It is concluded that since type V collagen is more resistant to collagenases, its decrease may predispose that particular site to rupture.
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