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  • Title: Antifibrinolytic therapy in the management of the Kasabach Merritt syndrome.
    Author: Ortel TL, Onorato JJ, Bedrosian CL, Kaufman RE.
    Journal: Am J Hematol; 1988 Sep; 29(1):44-8. PubMed ID: 3177369.
    Abstract:
    The Kasabach Merritt syndrome consists of thrombocytopenia, microangiopathic hemolytic anemia, and a localized consumption coagulopathy that develops within the abnormal vascular channels of a hemangioma. In general, these patients demonstrate only mild abnormalities of screening clotting tests, but they can potentially develop life-threatening complications. We present a patient who developed a severe anemia that was refractory to erythrocyte transfusions. Treatment with epsilon-aminocaproic acid to inhibit fibrinolysis and cryoprecipitate to replenish his deficient circulating fibrinogen interrupted the cycle of his systemic coagulopathy and enabled us to transfuse him to a normal hematocrit.
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